Amyloidosis is a rare but severe condition characterized by the atypical accumulation of amyloid proteins in various organs and tissues of the body. These amyloid deposits may disrupt normal organ function and cause various symptoms, depending on the affected organs. Early diagnosis is essential for effective management. While the condition might affect anyone, understanding these eight symptoms is crucial to help identify the condition and swiftly seek an expert’s opinion.

Fatigue and weakness
One of the initial indicators of amyloidosis is persistent fatigue and weakness. Individuals may notice a decline in their energy levels, often attributing it to stress or aging. However, when these symptoms persist and are not improved by rest, it’s essential to consider amyloidosis as a potential cause.

Swelling in the ankles and legs
Amyloidosis may lead to the accumulation of amyloid proteins in various organs, including the kidneys. As a result, some individuals may experience swelling, particularly in the ankles and legs. This swelling, known as edema, might be an early sign of kidney involvement in amyloidosis.

Unintended reduction of body mass
Unexplained reduction of body mass is another common early symptom of amyloidosis. Individuals may find themselves having a reduced BMI without making any significant changes to their meal plans or exercise routines. This loss might be gradual but persistent.

Irregular heartbeat
Amyloidosis might affect the heart, leading to symptoms such as irregular heartbeat. It may also result in shortness of breath and chest pain. These cardiac symptoms may not always be immediately associated with amyloidosis, but they warrant professional healthcare evaluation, especially when they occur in combination with other signs.

Numbness and tingling
Neuropathy, or nerve damage, is a potential complication of amyloidosis. Early signs may include numbness, tingling, or a “pins and needles” sensation in the extremities, such as the hands and feet. These neurological symptoms could interfere with daily activities.

Diarrhea
Amyloidosis might affect the digestive system, causing symptoms like diarrhea. It may also trigger other signs such as constipation and abdominal pain. These gastrointestinal issues may lead to nutritional deficiencies and further complications if left untreated.

Purple patches on the skin
In some cases, amyloid deposits may appear under the skin, causing visible changes. These may manifest as purple patches that may require immediate attention. One should also consult an expert if they notice nodules or waxy lumps on the skin’s surface.

Enlarged liver spleen
Amyloidosis may lead to the enlargement of the liver or spleen, which may be detected during a physical examination by a healthcare provider. This enlargement might cause discomfort or pain in the upper abdomen.